BSC at ICSB 2022

March 28-31st, 2022


The Botanical Safety Consortium will have a session at the International Conference on the Science of Botanicals (ICSB 2022) entitled “Botanical Safety Assessment: Updates from the BSC”. The meeting is taking place March 28th-31st, 2022.

A description of the session and talks are below.

The Botanical Safety Consortium (BSC) was officially convened in November 2019 as a public-private partnership aimed at enhancing the botanical safety toolkit and bringing clarity to botanical dietary ingredient safety assessments. This partnership is the result of a Memorandum of Understanding (MOU) between the US Food and Drug Administration (FDA), the National Institute of Health’s National Institute of Environmental Health Sciences (NIEHS), and the Health and Environmental Sciences Institute (HESI). The BSC serves as a forum for global scientists from government, academia, consumer health groups, industry, and non-profit organizations to work collaboratively to generate a sound scientific basis for integrating existing data and the latest toxicology tools to evaluate the safety of botanical dietary supplements. The objectives of the BSC are to identify pragmatic, fit-for-purpose, in vitro & in silico assays to evaluate botanical safety; establish the appropriate levels of chemical characterization for complex botanical products; evaluate the application of these tools via comparison to the currently available safety information; and integrate these tools and approaches into a framework that can facilitate robust evaluation of botanical substances. Initial endpoints of focus are chemical analysis, genotoxicity, hepatotoxicity & ADME, developmental & reproductive toxicity, and systemic toxicity. This presentation will provide a brief overview of the BSC goals and strategies, and its ongoing work.



  • 15 minutes: Introduction to the Botanical Safety Consortium – Dr. Holly Johnson (APHA)
  • 15 minutes: HPTLC Comparisons for Ashwagandha Root Extract – Dr. Anthony Fontana (Alkemist Labs)
  • 20 minutes: Constituent Identification and Quantification talk – Dr. Richard van Breemen (OSU)
  • 15 minutes: Method talk on Zebrafish embryos – Dr. Cammi Thornton (U Miss)
  • 15 Minutes: ADME modeling and hepatoxicity – Dr. Amy Roe (P&G)
  • 10 minutes: HESI Botanical Safety Consortium & Kamuzu University of Health Sciences Initiatives– Dr. Hellen Oketch (USP) and Dr. Stefan Gafner (ABC)