News
New publication: Advancing botanical safety
Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools. Waidyanatha et al., February 2024. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2024.114537 Increases in botanical use, encompassing herbal medicines and dietary supplements, have underlined a critical need for an advancement in safety assessment methodologies. This manuscript highlights: 1) Botanical Safety Consortium’s strategy for…
Read MoreNew publication in Food and Chemical Toxicology
Neuroactivity screening of botanical extracts using microelectrode array (MEA) recordings Regina G.D.M. van Kleef, Michelle R. Embry, Constance A. Mitchell, Remco H.S. Westerink. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2024.114438 The HESI Botanical Safety Consortium collaborates to develop screening strategies that can efficiently identify botanical-induced toxicity. The study presented here evaluates the applicability of in vitro multi-well microelectrode…
Read MoreNew publication in Regulatory Toxicology and Pharmacology
Improving the rigor and utility of botanical toxicity studies: Recommended resources Deval Patel, Barbara C. Sorkin, Constance A. Mitchell, Michelle R. Embry, Sharline Rina-Kong, Rebecca E. Adams, Emily R. DeTemple, Aalekhya Reddam, Stefan Gafner, Olaf Kelber, Cynthia V. Rider, Hellen Oketch-Rabah, Amy L. Roe, Robin J. Marles, Joseph Dever, Steven Dentali. Regulatory Toxicology and Pharmacology. https://doi.org/10.1016/j.yrtph.2023.105471…
Read MoreNew BSC Review
Potential pharmacokinetic interactions with concurrent use of herbal medicines and a ritonavir-boosted COVID-19 protease inhibitor in low and middle-income countries Dallas J. Smith, Huichang Bi, Josias Hamman, Xiaochao Ma, Constance Mitchell, Kumbukani Nyirenda, Tsitsi Monera-Penduka, Hellen Oketch-Rabah, Mary F. Paine, Syril Pettit, Wihan Pheiffer, Richard B. Van Breemen and Michelle Embry. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2023.1210579 In…
Read MoreBSC 2023 Annual Meeting
28 September 2023 Botanical Safety Consortium 2023 Annual Meeting held virtually on Thursday, September 28, 2023 from 9:00 – 3:30 (US Eastern). The meeting is free an open to all. Meeting flyer can be downloaded here. Videos Welcome & Meeting Objectives: Ms. Connie Mitchell, HESI Botanical Safety Consortium Introduction and Updates: Dr. Cynthia Rider,…
Read MoreASP2023 – Current Topics in Botanical Safety Workshop
22 July 2023, 1:30 – 4:30pm HESI Botanical Safety Consortium workshop on Saturday, 22 July from 1:30 – 4:30pm at the 2023 American Society of Pharmacognosy Annual Meeting in Rockville, Maryland. Current Topics in Botanical Safety Sponsored by: The Botanical Safety Consortium Chairs: Dr. Hellen O’Ketch-Rabah & Dr. Michelle Embry The growing popularity and interest…
Read MoreBSC Webinar: An In-Silico Method To Predict Cardiotoxicity In Botanical Substances
29 November 2022 The HESI Botanical Safety Consortium will host a webinar on Tuesday November 29 at 11 am ET from Dr. Jeremy Billson (InoCardia) entitled “An In-Silico Method To Predict Cardiotoxicity In Botanical Substances”. This work is a pilot project, using a predictive model for cardiovascular liabilities with botanical constituents. On the webinar Jeremy…
Read MoreBSC Annual Meeting
27 September 2022 Due to continued uncertainties with COVID-19, feedback from our stakeholders and the goals of the meeting, we have decided to make this year’s Botanical Safety Consortium’s Annual Meeting FULLY Virtual. The meeting will take place on 27 September. The full agenda can be viewed below and downloaded HERE. The meeting is free…
Read MoreBotanical Safety Consortium Stakeholder Council Webinar Series February 22, 2022 @ 11am EST
Chemical Safety of Phytomedicines – Perspectives for in vitro testing strategies? The Botanical Safety Consortium hosted an open webinar on Tuesday 22 February 11 am -12 pm ET. Webinar Title: Chemical Safety of Phytomedicines – Perspectives for in vitro testing strategies? Speaker: Dr. Dieter Schrenk, Senior Professor of Food Chemistry & Toxicology, University of Kaiserslautern…
Read MoreA public-private partnership to enhance the botanical safety toolkit
Botanical dietary supplement and herbal medicine use is increasing both in the United States and worldwide. Products made from botanicals can be variable in chemical composition, with many aspects affecting their quantitative and qualitative chemical content and unknown impacts on potential toxicity profiles. Many regulatory structures do not currently require toxicity data and only require…
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