BSC 2023 Annual Meeting

28 September 2023 Botanical Safety Consortium 2023 Annual Meeting held virtually on Thursday, September 28, 2023 from 9:00 – 3:30 (US Eastern). The meeting is free an open to all. Meeting flyer can be downloaded here.   Videos Welcome & Meeting Objectives: Ms. Connie Mitchell, HESI Botanical Safety Consortium Introduction and Updates: Dr. Cynthia Rider,…

SPS 2023 Annual Meeting

18 – 21 September 2023 HESI Botanical Safety Consortium Cardiotoxicty Technical Working Group poster at the 2023 Safety Pharmacology Society Annual Meeting in Brussels, Belgium.   P132: From neat compounds to complex mixtures: A potential screening strategy for cardiotoxic potential of botanicals. View full poster here. Go to Meeting Website

ETS 2023 Annual Meeting

17 – 20 September 2023 HESI Botanical Safety Consortium DART Technical Working Group poster at the 51st Annual Meeting of the European Teratology Society in Madrid, Spain. Go to Meeting Website

EMGS 2023 Annual Meeting

9 – 13 September 2023 HESI Botanical Safety Consortium Genotoxicity Technical Working Group poster presentation entitled “A Strategy for Developing a Robust Framework of Genotoxicity Assays for Safety Assessment of Botanicals” at the Environmental Mutagenesis & Genomics Society 54th Annual Meeting in Chicago, IL, USA. Go to Meeting Website

ASP2023 – Current Topics in Botanical Safety Workshop

22 July 2023, 1:30 – 4:30pm HESI Botanical Safety Consortium workshop on Saturday, 22 July from 1:30 – 4:30pm at the 2023 American Society of Pharmacognosy Annual Meeting in Rockville, Maryland. Current Topics in Botanical Safety Sponsored by:  The Botanical Safety Consortium Chairs:  Dr. Hellen O’Ketch-Rabah & Dr. Michelle Embry The growing popularity and interest…

71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)

July 5, 2023 BSC sponsored session on “Current Topics in Botanical Safety” at the 71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in Dublin, Ireland. View full program HERE

ICSB 2023

25 April 2023 HESI Botanical Safety Consortium session at the 21st International Conference on the Science of Botanicals (ICSB). ICSB Session 7a: Botanical Safety Assessment: Updates From The BSC Chair: Dan Marsman, Proctor & Gamble Location: OCC Auditorium Date:25 April 2023 at 1 pm-2:15 pm CT 1:00-1:25 Connie Mitchell, Health And Environmental Sciences Institute (HESI) – The…

Society of Toxicology 2023 Meeting

19-23 March 2023 HESI Botanical Safety Consortium at SOT2023 in person in Nashville. Symposium: New Approach Methodologies to Evaluate Botanical Safety, Monday 20 March, 1:45 pm – 4:30 pm Poster: Predicted Pharmacokinetic Properties of Botanical Constituents, Tuesday 21 March, 2:30 – 4:15 am Poster: A Potential Screening Strategy for Neuroactive Potential of Botanicals, Wednesday 22…

Toxicology Forum 2023 Winter Meeting

23 January 2023 HESI Botanical Safety Consortium event titled “Advancement of Botanical Safety Using New Approach Methodologies” at the Toxicology Forum 2023 Winter Meeting on January 23, 2023 from 1pm – 3pm EST. Link to the full program here: https://toxforum.site-ym.com/page/2023WinterMeetingProgram

BSC Webinar: An In-Silico Method To Predict Cardiotoxicity In Botanical Substances

29 November 2022 The HESI Botanical Safety Consortium will host a webinar on Tuesday November 29 at 11 am ET from Dr. Jeremy Billson (InoCardia) entitled “An In-Silico Method To Predict Cardiotoxicity In Botanical Substances“. This work is a pilot project, using a predictive model for cardiovascular liabilities with botanical constituents. On the webinar Jeremy…

Botanical Safety Consortium Summit 2024

Thursday October 10 and Friday October 11 2024 In-person: The National Institute of Environmental Health Sciences (NIEHS), Durham, NC, USA Virtual: TBA The Botanical Safety Consortium (BSC) will hold it’s first in-person meeting (with virtual option) at NIEHS in Durham, NC in October 2024. The in-person meeting is limited to members, with preference for steering…

New publication: Advancing botanical safety

Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools. Waidyanatha et al., February 2024. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2024.114537 Increases in botanical use, encompassing herbal medicines and dietary supplements, have underlined a critical need for an advancement in safety assessment methodologies. This manuscript highlights: 1) Botanical Safety Consortium’s strategy for…

New publication in Food and Chemical Toxicology

Neuroactivity screening of botanical extracts using microelectrode array (MEA) recordings Regina G.D.M. van Kleef, Michelle R. Embry, Constance A. Mitchell, Remco H.S. Westerink. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2024.114438 The HESI Botanical Safety Consortium collaborates to develop screening strategies that can efficiently identify botanical-induced toxicity. The study presented here evaluates the applicability of in vitro multi-well microelectrode…

International Congress on Natural Products Research (ICNPR)

13 – 17 July 2024 The Botanical Safety Consortium is holding a training course as part of the meeting on Saturday 13 July entitled “Cultivating Safety: Toxicology 101 of Botanicals and Natural Products.“ This course will offer a deep dive into the world of botanicals, bridging the gap between their traditional uses and modern applications in supplements,…

ICSB 2024

15 -18 April 2024 The Botanical Safety Consortium will be in attendance and presenting at the 22nd International Conference on the Science of Botanicals. Speakers include Connie Mitchell (HESI), and committee members Cynthia Rider (NIEHS), Amy Roe (P&G), Bill Gurley (U of Mississippi), and Holly Johnson (AHPA).

34th German Society for Environmental Mutation Research Meeting (GUM)

20 – 22 March 2024 The Botanical Safety Consortium will present two posters at the 34th German Society for Environmental Mutation Research Meeting (GUM). When: 20 – 22 March, 2024 Where: Kaiserslautern, Germany A Strategy for Developing a Robust Framework of Genotoxicity Assays for Safety Assessment of Botanicals The Botanical Safety Consortium: Collaborative Effort to…

SOT 2024

10 – 14 March 2024 The BSC will be presenting at SOT 2024 in Salt Lake City, UT, USA. Monday, March 11@1:45-4:30pm Symposium Session: Botanical-Induced Toxicity: Liver Injury and Botanical Drug Interactions, chaired by Amy Roe (P&G). BSC speakers include Steve Ferguson (NIEHS), Philip Yeager (US FDA), Mary Paine (Washington State University), Igor Koturbash (university Arkansas…

Botanical Safety Consortium: Introduction and Updates

18 January 2024 Connie Mitchell, Michelle Embry & Julie Krzykwa will be presenting to the US FDA Center for Food Safety and Applied Nutrition (CFSAN) to update the progress of the HESI Botanical Safety Consortium.

New publication in Regulatory Toxicology and Pharmacology

Improving the rigor and utility of botanical toxicity studies: Recommended resources Deval Patel, Barbara C. Sorkin, Constance A. Mitchell, Michelle R. Embry, Sharline Rina-Kong, Rebecca E. Adams, Emily R. DeTemple, Aalekhya Reddam, Stefan Gafner, Olaf Kelber, Cynthia V. Rider, Hellen Oketch-Rabah, Amy L. Roe, Robin J. Marles, Joseph Dever, Steven Dentali. Regulatory Toxicology and Pharmacology. https://doi.org/10.1016/j.yrtph.2023.105471…

New BSC Review

Potential pharmacokinetic interactions with concurrent use of herbal medicines and a ritonavir-boosted COVID-19 protease inhibitor in low and middle-income countries Dallas J. Smith, Huichang Bi, Josias Hamman, Xiaochao Ma, Constance Mitchell, Kumbukani Nyirenda, Tsitsi Monera-Penduka, Hellen Oketch-Rabah, Mary F. Paine, Syril Pettit, Wihan Pheiffer, Richard B. Van Breemen and Michelle Embry. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2023.1210579 In…

BOTANICAL SAFETY CONSORTIUM

A public-private partnership to improve botanical safety

The Botanical Safety Consortium (BSC) was officially convened in November 2019, as the result of a Memorandum of Understanding between the US Food and Drug Administration (FDA), the National Institutes of Health’s National Institute of Environmental Health Sciences (NIEHS), and the non-profit Health and Environmental Sciences Institute (HESI).

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Our current charge is to evaluate the suitability of assays for botanicals as complex mixtures.

Latest News

Botanical Safety Consortium Summit 2024

Thursday October 10 and Friday October 11 2024 In-person: The National Institute of Environmental Health Sciences (NIEHS), Durham, NC, USA Virtual: TBA The Botanical Safety Consortium (BSC) will…

New publication: Advancing botanical safety

Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools. Waidyanatha et al., February 2024. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2024.114537 Increases in botanical use,…

New publication in Food and Chemical Toxicology

Neuroactivity screening of botanical extracts using microelectrode array (MEA) recordings Regina G.D.M. van Kleef, Michelle R. Embry, Constance A. Mitchell, Remco H.S. Westerink. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2024.114438 The…

International Congress on Natural Products Research (ICNPR)

13 – 17 July 2024 The Botanical Safety Consortium is holding a training course as part of the meeting on Saturday 13 July entitled “Cultivating Safety: Toxicology 101 of Botanicals…

ICSB 2024

15 -18 April 2024 The Botanical Safety Consortium will be in attendance and presenting at the 22nd International Conference on the Science of Botanicals. Speakers include Connie Mitchell (HESI), and committee…

34th German Society for Environmental Mutation Research Meeting (GUM)

20 – 22 March 2024 The Botanical Safety Consortium will present two posters at the 34th German Society for Environmental Mutation Research Meeting (GUM). When: 20 – 22…

SOT 2024

10 – 14 March 2024 The BSC will be presenting at SOT 2024 in Salt Lake City, UT, USA. Monday, March 11@1:45-4:30pm Symposium Session: Botanical-Induced Toxicity: Liver Injury and…

Botanical Safety Consortium: Introduction and Updates

18 January 2024 Connie Mitchell, Michelle Embry & Julie Krzykwa will be presenting to the US FDA Center for Food Safety and Applied Nutrition (CFSAN) to update the…

New publication in Regulatory Toxicology and Pharmacology

Improving the rigor and utility of botanical toxicity studies: Recommended resources Deval Patel, Barbara C. Sorkin, Constance A. Mitchell, Michelle R. Embry, Sharline Rina-Kong, Rebecca E. Adams, Emily…

New BSC Review

Potential pharmacokinetic interactions with concurrent use of herbal medicines and a ritonavir-boosted COVID-19 protease inhibitor in low and middle-income countries Dallas J. Smith, Huichang Bi, Josias Hamman, Xiaochao…

The BOTANICAL SAFETY CONSORTIUM will provide a sound scientific basis for integrating existing botanical safety & toxicity information with the latest toxicological tools. 

This multi-partite, multi-stakeholder international effort will bring together key scientific experts to enhance the botanical safety toolkit and bring clarity to botanical dietary ingredient assessments.

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