Botanical Safety Consortium News

New publication: Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals

Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals. Roe et al., 2024. Journal of Dietary Supplements. https://doi.org/10.1080/19390211.2024.2417679   The HESI Botanical Safety Consortium‘s Hepatotoxicity Working Group has developed…

Read More

New publication: Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a Society of Toxicology Annual Meeting symposium

Koturbash et al., 2024. Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a Society of Toxicology Annual Meeting symposium. Regulatory Toxicology and Pharmacology. https://doi.org/10.1016/j.yrtph.2024.105708   This article addresses the growing public…

Read More

New publication: Chemical Standardization of Milk Thistle (Silybum marianum L.) Extract Using UHPLC-MS/MS and the Method of Standard Addition

A new paper from the HESI Botanical Safety Consortium describes the development and validation of a novel method for quantifying the constituents in milk thistle extracts to ensure consistency and reliability in…

Read More

New publication: Screening tools to evaluate the neurotoxic potential of botanicals: building a strategy to assess safety

A recent article from the Botanical Safety Consortium (BSC) Neurotoxicity Working Group aims to evaluate existing NAMs for neurotoxicity screening of botanicals as complex mixtures. The article provides background on three assays or…

Read More

New publication: Prediction of physicochemical and pharmacokinetic properties of botanical constituents by computational models

A newly published study from the Botanical Safety Consortium, selected for the cover of Journal of Applied Toxicology, used computational models to predict the physiochemical and pharmacokinetic properties of botanical constituents. …

Read More

New publication: Within-laboratory reproducibility of Ames test results: Are repeat tests necessary?

A cross-sector group of experts from the Health and Environmental Sciences Institutes (HESI)’s Botanical Safety Consortium (BSC) and Genetic Toxicology Technical Committee (GTTC) analyzed data from the National Toxicology Program (NTP) Ames test database…

Read More

New publication: Advancing botanical safety

Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools. Waidyanatha et al., February 2024. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2024.114537 Increases in botanical use, encompassing herbal…

Read More

New publication in Food and Chemical Toxicology

Neuroactivity screening of botanical extracts using microelectrode array (MEA) recordings Regina G.D.M. van Kleef, Michelle R. Embry, Constance A. Mitchell, Remco H.S. Westerink. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2024.114438 The HESI Botanical…

Read More

New publication in Regulatory Toxicology and Pharmacology

Improving the rigor and utility of botanical toxicity studies: Recommended resources Deval Patel, Barbara C. Sorkin, Constance A. Mitchell, Michelle R. Embry, Sharline Rina-Kong, Rebecca E. Adams, Emily R. DeTemple,…

Read More

New BSC Review

Potential pharmacokinetic interactions with concurrent use of herbal medicines and a ritonavir-boosted COVID-19 protease inhibitor in low and middle-income countries Dallas J. Smith, Huichang Bi, Josias Hamman, Xiaochao Ma, Constance…

Read More