Botanical Safety Consortium News
2025 Society for Birth Defects Research and Prevention Annual Meeting
28 June – 2 July 2025 The Botanical Safety Consortium will be presenting a poster at the 2025 Society for Birth Defects Research and Prevention Annual Meeting in Denver, Colorado. Date: Monday, June…
Read More
New publication: Integration of computational models to predict botanical phytochemical constituent clearance routes by the extended clearance classification system (ECCS)
Integration of computational models to predict botanical phytochemical constituent clearance routes by the extended clearance classification system (ECCS) Liu et al., 2025. Toxicology and Applied Pharmacology. https://doi.org/10.1016/j.taap.2025.117385 The Botanical Safety…
Read More
New publication: Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals
Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals. Roe et al., 2024. Journal of Dietary Supplements. https://doi.org/10.1080/19390211.2024.2417679 The HESI Botanical Safety Consortium‘s Hepatotoxicity Working Group has developed…
Read More
New publication: Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a Society of Toxicology Annual Meeting symposium
Koturbash et al., 2024. Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a Society of Toxicology Annual Meeting symposium. Regulatory Toxicology and Pharmacology. https://doi.org/10.1016/j.yrtph.2024.105708 This article addresses the growing public…
Read More
New publication: Chemical Standardization of Milk Thistle (Silybum marianum L.) Extract Using UHPLC-MS/MS and the Method of Standard Addition
A new paper from the HESI Botanical Safety Consortium describes the development and validation of a novel method for quantifying the constituents in milk thistle extracts to ensure consistency and reliability in…
Read More
New publication: Screening tools to evaluate the neurotoxic potential of botanicals: building a strategy to assess safety
A recent article from the Botanical Safety Consortium (BSC) Neurotoxicity Working Group aims to evaluate existing NAMs for neurotoxicity screening of botanicals as complex mixtures. The article provides background on three assays or…
Read More
New publication: Prediction of physicochemical and pharmacokinetic properties of botanical constituents by computational models
A newly published study from the Botanical Safety Consortium, selected for the cover of Journal of Applied Toxicology, used computational models to predict the physiochemical and pharmacokinetic properties of botanical constituents. …
Read More
New publication: Within-laboratory reproducibility of Ames test results: Are repeat tests necessary?
A cross-sector group of experts from the Health and Environmental Sciences Institutes (HESI)’s Botanical Safety Consortium (BSC) and Genetic Toxicology Technical Committee (GTTC) analyzed data from the National Toxicology Program (NTP) Ames test database…
Read More
New publication: Advancing botanical safety
Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools. Waidyanatha et al., February 2024. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2024.114537 Increases in botanical use, encompassing herbal…
Read More
New publication in Food and Chemical Toxicology
Neuroactivity screening of botanical extracts using microelectrode array (MEA) recordings Regina G.D.M. van Kleef, Michelle R. Embry, Constance A. Mitchell, Remco H.S. Westerink. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2024.114438 The HESI Botanical…
Read More