New publication: A multi-detector analytical approach for characterizing complex botanical extracts: a case study on ashwagandha.
A multi-detector analytical approach for characterizing complex botanical extracts: a case study on ashwagandha. Sica et al. Anal Bioanal Chem (2025). https://doi.org/10.1007/s00216-025-06006-8
Ensuring the safety and authenticity of botanical supplements starts with understanding what’s inside. In a new case study on ashwagandha, the HESI Botanical Safety Consortium showcases a multi-detector analytical platform designed to do just that.
This innovative approach combines *UHPLC, PDA, CAD, and HRMS to:
✔️ Identify and semi-quantify over 60 constituents
✔️ Support material authentication and detect variability
✔️ Enable in silico and in vitro safety evaluations
By generating detailed chemical fingerprints, this method helps advance consistent, science-based assessments of complex botanical products—contributing to both consumer confidence and product innovation.
Read the publication: https://doi.org/10.1007/s00216-025-06006-8
* Ultra-high-performance liquid chromatography (UHPLC) coupled with photodiode array (PDA) detection, charged aerosol detection (CAD), and high-resolution mass spectrometry (HRMS)
